Sepsis is a systemic inflammatory state due to an infection, and is associated with very high mortality and morbidity. Early diagnosis and prompt antibiotic and supportive therapy is associated with improved outcomes. Bacteremia (presence of bacteria in blood) along with a systemic inflammatory response denotes sepsis. Sepsis is responsible for nearly 10% of the ICU admissions in the United States, totaling about 1 million cases nationwide every year (1). The incidence rate of severe sepsis in the United States is about 300 per 100,000 persons per year, with a total of 750,000 cases nationwide per year. Direct costs per sepsis patient for ICU treatment in the United States have been estimated at more than $40,000. The risk of mortality increases by 7.6% with every 1 hour delay in administering antibiotic therapy in septic shock patients with hypotension (2-3).
PCR-based tests for the early diagnosis of sepsis. Where do we stand?(4) Rapid and accurate identification of the cause of sepsis is essential in improving patient outcomes. Early identification of these pathogens by nucleic acid detection assays directly from blood samples remains key to achieving this, particularly if taken at the time of presentation. Selection of the most suitable PCR system is typically influenced by local epidemiology and by the resources of the testing laboratory.
PCRopsis Blood can speed-up the detection of bacteria in blood samples by enabling testing laboratories to perform direct PCR from clinical samples without having to isolate DNA.
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